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Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.

Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children.

Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified ARas mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. (J Allergy Clin Immunol 2012;130:1049-62.)

Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified ARas mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. in its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. (J Allergy Clin Immunol 2012;130:1049-62.) ; Stallergenes ; ALK-Abello ; European Academy of Allergy and Clinical Immunology (EAACI) ; MSD ; Novartis ; Nycomed/Takeda ; PHADIA/Thermo Fischer ; 3M ; AstraZeneca ; GlaxoSmithKline ; Merck Frosst ; Altair ; Amgen ; Asmacure ; Boehringer-Ingelheim ; Genentech ; Pharmaxis ; Schering ; Wyeth ; Ache ; Brazilian Research Council ; Fundacao de Amparo a Pesquisa da Bahia ; Fundacao Ciencia e Tecnologia ; Sociedade Portuguesa de Alergologia e Immunologia Clinica ; Abdi Ibrahim ; OrionPharma ; Nasonebs ; Merck ; McNeal ; Chiesi ; Nycomed ; Air Liquid Healthcare ; Mundipharma ; Almirall ; Kyorin ; Teva ; UK National Health Service ; Aerocrine ; AKL Ltd ; PREDICTA ; Swiss National Science Foundation ; MeDALL ; Global Allergy and Asthma European Network (GA 2LEN) ; Christine Kuthe Center for Allergy Research and Education ; Faes Farma ; Bial ; Johnson Johnson ; Sanofi ; HAD treasurer ; Innovative Medicine Initiative (EU) ; Helse Sor-Ost RHF (Southern and Eastern Norway Regional Health Authority) ; MEDA ; Alcon ; ISTA ; Thermo-Fisher ; Airsonett ; Medical Research Council ; Moulton Charitable Trust ; AB Science ; Canadian Institutes for Health Research ; AllerGen NCE ; Merck/Schering-Plough ; Circassia ; University Hospital ; Medical School of Universidad Autonoma de Nuevo Leon, Mexico ; Children's Research Foundation (Ireland) ; Danone ; Food Standards Agency (United Kingdom) ; European Union (EU) ; DTG ; Netherlands Asthma Foundation ; Merck-Sharp-Dohme, Mexico ; Allerquim Mexico ; Abbott ; Apotex ; HRA ; MedImmune ; Schering-Plough ; Proctor Gamble ; Sunovion (Sepracor) ; Phadia ; Servier ; CSC JohnsonJohnson ; Oxygen Plus ; New Medics ; European Respiratory Society ; Societe de Pneumologie de Langue Francaise Asthma ; Ministry of Health, Welfare, and Labor ; Altana ; Takeda ; UCB ; Uriach advisory board ; NAPP ; Royal College of GPs Clinical Champion in Allergy ; Agency for Healthcare Research and Quality (AHRQ) ; AnseII ; Bayer Schering ; OST ; Fujisawa ; IHAL ; Henkel ; Kryolan ; Leti ; MSO ; Procter and Gamble ; Sanofi-Aventis ; Scientific Advisory Board for the German Society for Allergy and Clinical Immunology ; German Federal Ministry of Consumer Protection ; European Centre for Allergy Research Foundation (ECARF) ; Hop Arnaud Villeneuve, Dept Resp Dis, Univ Hosp, Montpellier, France ; INSERM, U1018, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, Villejuif, France ; McMaster Univ, Dept Clin Epidemiol & Biostat & Med, Hamilton, ON, Canada ; Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland ; Univ Hosp Montpellier, Hop Arnaud Villeneuve, INSERM, U657, Montpellier, France ; Catholic Univ, Fac Med, Res Ctr Resp Med CIMER, Cordoba, Argentina ; Univ Genoa, Sch Specializat, Genoa, Italy ; Univ Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, B-9000 Ghent, Belgium ; CNR, Inst Translat Pharmacol, Rome, Italy ; Univ Naples 2, Naples, Italy ; Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada ; Univ Genoa, Dept Internal Med, DIMI, I-16126 Genoa, Italy ; Creighton Univ, Dept Med, Div Allergy & Immunol, Omaha, NE 68178 USA ; Univ Fed Bahia, ProAR Nucleo Excelencia Asma, Salvador, BA, Brazil ; CNPq, Salvador, BA, Brazil ; Univ Amsterdam, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands ; Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands ; Univ Porto, Sch Med, Dept Hlth Informat & Decis Sci, P-4100 Oporto, Portugal ; Univ Porto, Sch Med, CINTESIS, P-4100 Oporto, Portugal ; Hosp S Joao & Inst, Dept Allergy, Oporto, Portugal ; Hosp CUF Porto, Oporto, Portugal ; Erasmus MC, Dept Internal Med, Sect Allergol, Rotterdam, Netherlands ; Univ Washington, Sch Med, Seattle, WA USA ; Helsinki Univ Hosp, Dept Allergy, Skin & Allergy Hosp, Helsinki, Finland ; GARD ARIA Coordinator, Geneva, Switzerland ; Med Univ Lodz, Dept Internal Med Asthma & Allergy, Barlicki Univ Hosp, Lodz, Poland ; Univ S Florida, Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33612 USA ; James A Haley Vet Hosp, Tampa, FL USA ; Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway ; CIBERES, IDIBAPS, Hosp Clin, Rhinol Unit,ENT Dept, Barcelona, Spain ; CIBERES, IDIBAPS, Hosp Clin, Smell Clin,ENT Dept, Barcelona, Spain ; Univ Chicago, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA ; Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia ; Monash Univ, Melbourne, Vic 3004, Australia ; Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol, Tokyo 173, Japan ; EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium ; Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece ; Nippon Med Sch, Bunkyo Ku, Tokyo 113, Japan ; Univ Aberdeen, Dept Primary Care Resp Med, Aberdeen, Scotland ; Woodbrook Med Ctr, Loughborough, Leics, England ; Univ Edinburgh, Edinburgh, Midlothian, Scotland ; Univ Manitoba, Fac Med, Winnipeg, MB, Canada ; NIAID, Bethesda, MD 20892 USA ; Univ N Carolina, Sch Pharm, Chapel Hill, NC USA ; Celal Bayar Univ, Sch Med, Dept Pulmonol, Manisa, Turkey ; Allergy & Asthma Inst, Islamabad, Pakistan ; Med Univ Graz, Dept Dermatol, Graz, Austria ; Showa Univ, Sch Med, Div Allergol & Resp Med, Tokyo 142, Japan ; Transylvania Univ, Fac Med, Brasov, Romania ; Int Union TB & Lung Dis Union, Paris, France ; Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland ; Minist Hlth, Publ Hosp Med Serv, Antananarivo, Madagascar ; INSERM, EPAR U707, Paris, France ; Univ Paris 06, EPAR, UMR S, Paris, France ; Hosp Quiron Bizkaia, Dept Allergy & Immunol, Erandio Bilbao, Spain ; Univ Cape Town, Dept Med, Fac Hlth Sci, Div Pulmonol, ZA-7925 Cape Town, South Africa ; WHO, Collaborating Ctr Asthma & Rhinitis, Montpellier, France ; Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena, Italy ; Ctr Hosp Univ Rabta, Serv Pneumol Allergol, Tunis, Tunisia ; Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1105 AZ Amsterdam, Netherlands ; Hop Mami, Ariana, Tunisia ; Bangladesh Lung Fdn, Dhaka, Bangladesh ; Natl Inst Dis Chest & Hosp, Dhaka, Bangladesh ; Charite, Dept Dermatol, Allergy Ctr Charite, D-13353 Berlin, Germany ; Univ Med Ctr, Dept Dermatol & Allergy, Bonn, Germany ; Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark ; Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark ; Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA ; Univ Verona, Dept Paediat, I-37100 Verona, Italy ; Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada ; Hop Malbaie, La Malbaie, PQ, Canada ; Univ Leicester, Inst Lung Hlth, Leicester LE1 7RH, Leics, England ; Royal Brompton Hosp, Dept Paediat Resp Med, London SW3 6LY, England ; Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sect Allergy & Clin Immunol, London, England ; Ctr Med Docente La Trinidad Caracas, Dept Immunol, Caracas, Venezuela ; Univ Austral Chile, Fac Med, Dept Pediat, Valdivia, Chile ; Univ Fed Sao Joao del Rei, Hlth Sci Ctr, Hlth Sci Postgrad Program, Divinopolis, Brazil ; Univ Cartagena, Immunol Res Inst, Cartagena de Indias, Colombia ; So Calif Res, Mission Viejo, CA USA ; Metropolitan Univ Barranquilla, Allergy & Immunol Lab, Barranquilla, Colombia ; IRCCS San Raffaele Pisana, Rome, Italy ; Univ Cattolica Sacro Cuore, Dept Thorac Surg, Rome, Italy ; Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands ; Capital Inst Pediat, Asthma Clin, Natl Cooperat Grp Pediat Res Asthma, Beijing, Peoples R China ; Capital Inst Pediat, Educ Ctr, Beijing, Peoples R China ; Ctr Asthma Res & Educ, Beijing, Peoples R China ; Hop Arnaud Villeneuve, Univ Hosp, Allergy Unit, Montpellier, France ; Univ Hosp, Dept Allergol, Sch Med CEU San Pablo Madrid, Madrid, Spain ; Georgian Natl Univ, AIETI Med Sch, SEU Clin, Med Ctr, Tbilisi, Rep of Georgia ; Univ Genoa, Dept Internal Med, IRCCS Azienda Osped Univ San Martino, I-16126 Genoa, Italy ; Univ Montpellier I, Primary Care Dept, Montpellier, France ; Nova SE Univ, Coll Osteopath Med, Davie, FL USA ; Univ Manchester, Manchester, Lancs, England ; Aarhus Univ Hosp, Dept Resp Dis, DK-8000 Aarhus, Denmark ; Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany ; TUM, Div Environm Dermatol, Munich, Germany ; TUM, Allergy Helmholtz Ctr, Munich, Germany ; Univ Hosp Strasbourg, Chest Dis Dept, Div Pulmonol Asthma & Allergol, Strasbourg, France ; Univ Med & Pharm Iuliu Hatieganu, Dept Allergy, Med Clin 3, Romanian Soc Allergy & Clin Immunol, Cluj Napoca, Romania ; McMaster Univ, AllerGen NCE, Dept Med, Hamilton, ON, Canada ; McMaster Univ, AllerGen NCE, Michael G DeGroote Sch Med, Div Clin Immunol & Allergy,Fac Hlth Sci, Hamilton, ON, Canada ; Univ Versailles St Quentin, Hop Foch, UPRES EA 220, Suresnes, France ; Ctr Hosp Reg Annecy, Serv Pneumol, Annecy, France ; Univ Ss Cyril & Methodius, Univ Clin Pulmonol & Allergy, Skopje, Macedonia ; Georgia Hlth Sci Univ, Augusta, GA USA ; Ctr Hosp Univ Beni Messous, Serv Pneumoallergol, Algiers, Algeria ; Vilnius Univ, Fac Med, Collaborating Ctr GA2LEN, Vilnius, Lithuania ; Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England ; Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA ; Ain Shams Univ, Childrens Hosp, Pediat Allergy & Immunol Unit, Cairo, Egypt ; Egyptian Soc Pediat Allergy & Immunol, Cairo, Egypt ; Soc Marocaine Malad Resp, Casablanca, Morocco ; Ctr Resp Dis & Allergy, Casablanca, Morocco ; Vilnius Univ, Fac Med, Vilnius, Lithuania ; Univ Milan, Sch Med, Melloni Hosp, Milan, Italy ; Educ Hlth, Warwick, England ; Dokkyo Med Univ, Mibu, Tochigi, Japan ; WHO, Country Off Georgia, Tbilisi, Rep of Georgia ; Clin Ricardo Palma, Lima, Peru ; Univ Nuevo Leon UANL, Hosp Univ, Fac Med, Monterrey, Mexico ; Ctr Allergy & Immunol, Tbilisi, Rep of Georgia ; Clin Hosp Univ Chile, Dept Med, Immunol & Allergol Div, Santiago, Chile ; Univ Hosp Leuven, Dept Otorhinolaryngol Head & Neck Surg, Louvain, Belgium ; Cent Reg Denmark, Ctr Publ Hlth & Qual Improvement, Aarhus, Denmark ; Allergy Ctr Vienna W, Vienna, Austria ; Natl Univ Ireland Univ Coll Cork, Dept Paediat & Child Hlth, Cork, Ireland ; Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England ; Univ Paris 11, Serv Pneumol, Hop Antoine Beclere, AP HP,INSERM,U999, Clamart, France ; Salvador Univ, Sch Med, Dept Immunol, Buenos Aires, DF, Argentina ; Univ St Andrews, St Andrews, Fife, Scotland ; Univ Paris, APHP, Ctr Asthme & Allergies, Grp Hosp Trousseau La Roche Guyon, F-75252 Paris, France ; Hacettepe Univ, Sch Med, Pediat Allergy & Asthma Unit, Ankara, Turkey ; George Washington Univ, Sch Med, Washington, DC USA ; Inst Asthma & Allergy, Chevy Chase, MD USA ; Hacettepe Univ Hosp, Dept Chest Dis, Adult Allergy Unit, Ankara, Turkey ; Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany ; McMaster Univ, Hamilton, ON, Canada ; Hotel Dieu France, Serv Pneumol & Reanimat Med, Beirut, Lebanon ; Univ St Joseph, Fac Med, Beirut, Lebanon ; Natl Med Ctr, Seoul, South Korea ; Seoul Natl Univ, Seoul, South Korea ; Korea Asthma Allergy Fdn, Seoul, South Korea ; Ctr Hosp Univ, Serv Malad Resp, Abidjan, Cote Ivoire ; Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Beatrix Childrens Hosp,Dept Pediat Pulmonol & Ped, Groningen, Netherlands ; Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland ; Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden ; Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden ; Vilnius Univ, Ctr Pulmonol & Allergol, Vilnius, Lithuania ; Vilnius Univ Hosp Santariskiu Klinikos, Vilnius, Lithuania ; Hosp Med Sur, Dept Allergy, Mexico City, DF, Mexico ; Univ Med & Pharm, Thanh Pho Ho Chi Minh, Vietnam ; Hop Sacre Coeur Montreal, Montreal, PQ, Canada ; Univ Montreal, Montreal, PQ, Canada ; Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China ; Univ Tennessee, Coll Med, Memphis, TN USA ; Univ Dundee, Ninewells Hosp, Asthma & Allergy Res Grp, Dundee, Scotland ; Dubai Hlth Author, Sharjah, U Arab Emirates ; Univ Sharjah, Sharjah, U Arab Emirates ; Univ Mississippi, Med Ctr, Div Clin Immunol & Allergy, Jackson, MS 39216 USA ; Univ Arizona, Coll Med, Arizona Resp Ctr, Tucson, AZ USA ; Univ Arizona, Inst BIO5, Tucson, AZ USA ; Shahid Beheshti Univ Med Sci, NRITLD, Tehran, Iran ; Shahid Beheshti Univ Med Sci, Chron Resp Dis Res Ctr, Tehran, Iran ; Charite, Dept Dermatol & Allergy, D-13353 Berlin, Germany ; Maputo Cent Hosp, Dept Peadiat, Maputo, Mozambique ; Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique ; Childrens Hosp La Fe, Unit Pediat Allergy & Pneumol, Valencia, Spain ; Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden ; Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden ; Univ Calif San Diego, Allergy & Asthma Med Grp, San Diego, CA 92103 USA ; Univ Calif San Diego, Res Ctr, San Diego, CA 92103 USA ; IMSS, Dept Allergy & Clin Immunol, Ctr Med Nacl Siglo 21, Mexico City, DF, Mexico ; Univ Aachen, Dept Dermatol, Aachen, Germany ; Inst Pneumol Marius Nasta, Bucharest, Romania ; Tishreen Univ, Sch Med, Dept Internal Med, WHO EMRO Collaborating Ctr Training & Res Chron R, Latakia, Syria ; CUF Descobertas Hosp, Immunoallergy Dept, Lisbon, Portugal ; Univ Padua, Dept Pediat, Food Allergy Referral Ctr Veneto Reg, Padua, Italy ; Mustapha Hosp, Algiers, Algeria ; Sci Ctr Childrens Hlth RAMS, Moscow, Russia ; Hosp Hospitaller Bros Buda, Budapest, Hungary ; Charite, Allergie Ctr Charite ECARF, Dept Dermatol Venerol & Allergy, D-13353 Berlin, Germany ; German Red Cross Hosp Westend, Berlin, Germany ; Jagiellonian Univ, Sch Med, Dept Pulmonol, Krakow, Poland ; Kinshasa Univ, ENT Dept, Kinshasa, Zaire ; Chiba Univ Hosp, Dept Otorhinolaryngol, Chiba, Japan ; Nippon Med Sch, Dept Otolaryngol, Bunkyo Ku, Tokyo 113, Japan ; Ctr Hosp Univ Pediat Charles de Gaulle, Ouagadougou, Burkina Faso ; Marmara Univ, Div Pediat Allergy & Immunol, Istanbul, Turkey ; Mem Hlth Grp, Istanbul, Turkey ; Charles Univ Prague, Fac Med Plzen, Dept Immunol & Allergol, Prague, Czech Republic ; MESSERLI Res Inst, Vienna, Austria ; Med Univ Vienna, Univ Vet Med Vienna, Vienna, Austria ; Univ Vienna, Vienna, Austria ; Ajou Univ, Sch Med, Suwon 441749, South Korea ; NICE, Paris, France ; Soc Pneumol Langue Francaise, Paris, France ; Krankenhaus Hietzing, Karl Landsteiner Inst Expt & Clin Pneumol, Dept Pulm Med, Vienna, Austria ; Alexanders Univ Hosp, Clin Allergy & Asthma, Sofia, Bulgaria ; Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Dept Pulmonol, Groningen, Netherlands ; Univ Cape Town, Lung Inst, ZA-7925 Cape Town, South Africa ; Groote Schuur Hosp, ZA-7925 Cape Town, South Africa ; Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands ; Grosshansdorf Clin, Grosshansdorf, Germany ; Hop Prive Athis Mons, Serv Pneumol, Athis Mons, France ; Helsinki Univ Hosp, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland ; Tech Univ Munich, CKCARE, Dept Dermatol Allergy Biederstein, Munich, Germany ; Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA ; Med Univ Silesia, Dept & Clin Internal Dis Allergol & Clin Immunol, Katowice, Poland ; Complesso Integrato Columbus, Allergy Unit, Rome, Italy ; IRCCS Oasi Maria SS, Troina, Italy ; Son Pisa Primary Care Ctr, IB Salut Balear Hlth Serv, Int Primary Care Resp Grp, Palma de Mallorca, Spain ; Hosp Luz, Immunoallergy Dept, Lisbon, Portugal ; Univ Missouri, Kansas City Sch Med, Kansas City, MO 64110 USA ; Childrens Mercy Hosp, Kansas City, MO USA ; Emek Med Ctr, Afula, Israel ; Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel ; Ctr Med Docente La Trinidad, Dept Allergy & Clin Immunol, Caracas, Venezuela ; UCL, Royal Natl TNE Hosp, London, England ; Univ Zurich Hosp, Dept Dermatol, Allergy Unit, CH-8091 Zurich, Switzerland ; Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Allergy & Resp Res Grp, Edinburgh, Midlothian, Scotland ; Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil ; Natl Ctr Cardiol & Internal Med, Bishkek, Kyrgyzstan ; Ctr ACI Immunoflow, Czech Initiat Asthma, Prague, Czech Republic ; GAAPP, Vienna, Austria ; Ctr Res Environm Epidemiol CREAL, Barcelona, Spain ; Pontificia Univ Catolica RGS, Sch Med, Porto Alegre, RS, Brazil ; Univ Nevada, Sch Med, Reno, NV 89557 USA ; Hosp Mar, Municipal Inst Med Res IMIM, Barcelona, Spain ; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain ; Univ Pompeu Fabra UPF, Barcelona, Spain ; Jagiellonian Univ, Coll Med, Krakow, Poland ; Coimbra Univ Hosp, Immunoallergy Dept, Coimbra, Portugal ; Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA ; Finnish Inst Occupat Hlth, Helsinki, Finland ; Univ Laval, Fac Med, Dept Obstet & Gynecol, Laval, PQ, Canada ; Med Univ Vienna, Christian Doppler Lab Allergy Res, Div Immunopathol, Dept Pathophysiol & Allergy Res,Ctr Pathophysiol, Vienna, Austria ; Hosp Clin Barcelona, Dept Pneumol, Allergy Unit, Immunoallergia Resp Clin, Barcelona, Spain ; IDIBAPS, Barcelona, Spain ; CIBERES, Barcelona, Spain ; Univ Paris 13, Bobigny, France ; Avicenne Hosp, AP HP, Bobigny, France ; Vilnius Univ, Fac Med, Dept Paediat, Vilnius, Lithuania ; Lithuanian Natl Council Childs Hlth, Vilnius, Lithuania ; Terveystalo Turku, Allergy Clin, Turku, Finland ; Univ Turku, Dept Lung Dis & Clin Immunol, Turku, Finland ; Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium ; Catholic Univ Louvain, Univ Hosp Mt Godinne, Yvoir, Belgium ; Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, NL-6525 ED Nijmegen, Netherlands ; Siriraj Hosp, Fac Med, Dept Pediat, Bangkok, Thailand ; CNR, IBIM, Palermo, Italy ; Clin Physiol IFC, Pisa, Italy ; Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore ; Floridsdorf Allergy Ctr FAZ, Vienna, Austria ; Med Univ Vienna, Dept Dermatol, DIAID, Vienna, Austria ; Bradford Teaching Hosp Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England ; Olmsted Med Ctr, Dept Res, Rochester, MN USA ; Univ Minnesota, Dept Family & Community Hlth, Rochester, MN USA ; Harvard Univ, Sch Publ Hlth, Cyprus Int Inst Environm & Publ Hlth Assoc, Limassol, Cyprus ; Cyprus Univ Technol, Limassol, Cyprus ; Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, ZA-7925 Cape Town, South Africa ; Catholic Univ Cordoba, Sch Med, Dept Otorhinolaryngol, Cordoba, Argentina ; Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China ; Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China ; Univ Clin Resp & Allerg Dis, Golnik, Slovenia ; Charite, Network Excellence, Global Allergy & Asthma European Network GA2LEN, D-13353 Berlin, Germany ; Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil ; Web of Science